Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles.
نویسندگان
چکیده
Self-assembled cholesterol-asplatin-incorporated nanoparticles (SCANs) were prepared for oral delivery of a Pt(IV) prodrug. SCANs exhibit high gastrointestinal stability, sustained drug release and enhanced cell uptake. The oral bioavailability of SCANs was 4.32-fold higher than that of free Pt(IV) prodrugs. The oral administration of SCANs efficaciously inhibits tumor growth with negligible toxicity.
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عنوان ژورنال:
- Chemical communications
دوره 51 99 شماره
صفحات -
تاریخ انتشار 2015